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TBI-induced neuroinflammation further intensifies this metabolic reprogramming, with activated microglia releasing pro-inflammatory factors like IL-6 and TNF, enhancing glycolysis while suppressing OXPHOS through TLR signaling pathways (190)

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Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis

in the remission phase, they maintain gut microbial balance and promote immune tolerance to reduce recurrence risk

However, it is important to note that the ferroptosis-protective role of DHODH remains a matter of ongoing debate and appears to be highly context- and cell-type-dependent [94]

Consequently, they benefit from breast milk, a potent form of chrononutrition, with its composition varying according to the mothers circadian rhythms