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Description

BRD4 negatively regulates ferroptosis by activating xCT, repairing the DNA, and inducing senescence-associated secretory phenotype (SASP), a ferroptosis resistant cellular program (Tasdemir et al., 2016

Breed 41, 25

This is a reasonable position, and it is one of the arguments the July panel will need to weigh carefully against the absence of rigorous human trial data