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(2017): Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study

doi: 10.1186/s12950-019-0207-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 196

Although the 2 sets of data initially have similar rates of DNA rejoining, the AT cells have increased numbers of residual DNA double-strand breaks relative to controls at later times postirradiation

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(Figure 3B), which is consistent with our previous results

Third, translational gaps between preclinical models and clinical practice are prominent: most therapeutic candidates (e.g., natural products and repurposed drugs) have only been validated in rodent models, with limited data on human renal tissue responses, optimal dosing windows, or potential drugdrug interactions in clinical settings (e.g., in patients undergoing kidney transplantation or cardiovascular surgery)