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Chelation is among the potential mechanisms that largely govern metal-tolerance in plant cells by maintaining low concentrations of free metals in cytoplasm

10.1038/s41598-020-64521-3 40 GuoZ.LiuY.ChenD.SunY.LiD.MengY.et al (2025)

J Alzheimers Dis 90:15011521 Hashim KNB, Matsuba Y, Takahashi M, Kamano N, Tooyama I, Saido TC, Hashimoto S (2024) Loss of glutathione elevates the A42/A40 ratio and the aggregation of the tau protein

Collectively, GGCT functions as a metabolic rheostat that orchestrates mitochondrial homeostasis through diverting Gln flux toward glutathione biosynthesis to fortify redox defense, while enhancing Glc-fueled TCA cycle anaplerosis to sustain cell proliferation

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

One of its proposed mechanisms of action is the preservation of glutathione levels in cardiomyocytes, thereby protecting against oxidative stress [99,100]