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Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer

PLoS ONE 8 , e74658 (2013)

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However, you should seek immediate medical attention if you experience signs of a serious reaction such as difficulty breathing, chest tightness, severe dizziness, rapid heartbeat, widespread rash, swelling of the face or throat, or severe injectionsite reactions like intense pain, significant swelling, or signs of infection (redness, warmth, pus, or fever)

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However, there may be other causes why some people with B12 deficiency require more frequent injections