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The samples were homogenized using D2400 BeadBlaster homogenizer (Benchmark Scientific) then centrifuged at 21,000 g for 3 min

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There is a high degree of correlation between the ATAC-seq groups and RNA-seq clusters in both direction and timing of differential chromatin accessibility and gene expression ( Figure 2D ), showing that the BDG-induced changes in chromatin accessibility are associated with transcriptional changes of proximal genes