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10.1016/j.coph.2006.08.011 Curr

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In contrast, periosteal cells with Ad/AAV-induced IGF-1 expression maintained a chondrocyte-like phenotype and produced a hyaline-like matrix with intense intracellular HIF-1 staining in the regenerated tissue area

Emodin decreases GSH content, xCT and GPX4 expression, increases ROS generation, MDA, and lipid peroxidation, effects reversed by ferroptosis inhibitors and autophagy inhibitors, iron chelator DFO, ferostatin-1, and NCOA4 silencing