l carnitine fatty acid transport mitochondria role Shuttle l-carnitine transports fatty acids into

In ME/CFS, pro-inflammatory cytokines such as IL-1, IL-4, IL-5, TNF-, IL-10, IFN-, IL-12, and lymphotoxin- (LTA) are increased

The polyphenols ability to cross the blood-brain barrier facilitates direct neural tissue intervention, promoting neurogenesis, enhancing synaptic plasticity, and potentially modulating neuroinflammatory responses

However, ongoing studies have revealed that the multifaceted role of IFNs in the antitumor response during anti-PD treatment involves not only the classical JAK-STAT signaling pathway but also various noncanonical pathways that can lead to diverse outcomes, contributing to either tumor progression or tumor regression under certain conditions

GY: Conceptualization, Project administration, Writing review & editing, Methodology, Supervision

6.3 Critical assessment and challenges of SSP-targeted therapy 6.3.1 Target specificity and toxicity evaluation in normal tissues The SSP is not only aberrantly activated in tumor cells but also participates in fundamental metabolism in normal tissues, including the nervous system, immune cells and the liver

10.1007/s10341-015-0238-6 75 JangS