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Weeks 12 to 20: Most patients see their clearest results during this window, with consistent protocol adherence

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The blood-ocular barrier (BOB) includes the blood-aqueous barrier (BAB) located in the anterior segment of the eye and the blood-retinal barrier (BRB) located in the posterior segment of the eye, which can restrict the entry of drugs from the blood into the eye and is the main obstacle in treating eye diseases (Varela-Fernandez et al., 2020), as they can bypass more anterior barriers such as tear film, cornea, and sclera, but may cause injection related complications