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Endocrinology 152:468475 Yakar S, Isaksson O (2016) Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: lessons from mouse models

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Notably, deficiency of TMEM175 , which encodes a K channel, induces excessive lysosomal acidification rather than deacidification, yet similarly results in reduced cathepsin activity and impaired Syn aggregation in vitro and in vivo tissues