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Introduction Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with a relapsing-remitting course characterized by pruritus, dry skin, and eczema lesions ( Among all of the inflammatory cytokines, TNF- has gained a lot of attention due to its multiple effects in promoting cells death, including receptor-interacting protein 1 (RIP1)-independent apoptosis, RIP1-dependent apoptosis (RDA), and necroptosis ( As the main bioactive component of tea polyphenols, the health benefits of epigallocatechin-3-gallate (EGCG) have been widely used in treating a wide range of diseases, based on its anti-inflammatory and antioxidant properties ( However, the low bioavailability, instability, and cytotoxicity at a large dose limited the clinical application of EGCG

Therefore, for researchers aiming for precise dosing, long-term stability, and GMP-compliant scalability, liposomal encapsulation remains the superior strategy

Alongside medical management, diet and nutrition play an important role in supporting gut health and reducing symptom flare-ups

Janky R, Ogita K, Pasqualotto BA, Bains JS, Oja SS, Yoneda Y, Shaw CA