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The 5-phase titration schedule Phase 1 (Weeks 1 through 4): 0.25mg per week This is the initiation phase

90-95% (thats a lot) is lost in digestion & flushed out of our system (rendering it relatively pointless) by the kidneys

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[DOI] [PMC free article] [PubMed] [Google Scholar] 339.Wolfram-Schauerte, M

In a subsequent mechanistic study, they found that MET first activated the MAPK signaling pathway, followed by the activation of the downstream NF-B-mediated p65 transcription factor, which interacted with the proximal region of the PD-L1 promoter to promote PD-L1 expression [133]