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The findings stimulate further studies in large biobank samples to clarify whether such signatures could prove valuable for detecting pathology or follow-up of treatment effect in clinical trials

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In response to stimulation by ACTH, the adrenal glands secrete both cortisol and AA, 14 likely because vitamin C is essential for cortisol normalization in times of stress adaption

In vitro experiments have demonstrated that bioactive LMW-HA fragments may drive an inflammatory matrix environment via eosinophils and directly impair gamete quality by compromising granulosa cell function, thereby contributing to reproductive aging 98

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This modulation helps to maintain the integrity of epithelial tissues and supports immune cell function, which is critical for donors to recover effectively after blood donation [297]