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Coschigano, K

In vivo pharmacokinetic evaluation showed that these SLNs increased oral bioavailability by 4.3-fold compared with the marketed formulation, highlighting their ability to overcome poor solubility and first-pass metabolism [83]

Additional analyses of clinical trials data by race or ethnicity are necessary but are not feasible with the GOLDEN 3 and 4 studies due to the majority Caucasian patient population

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

J Mol Biol 234:938945