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doi: 10.1177/0269881115599386 80 KrupaAebkowskaAKondraciukMKaminskiKAKowalskaI

Long-term safety aspects of systemic therapy with fumaric acid esters in severe psoriasis

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When exposed to ROS, Nrf2 migrates from the cytoplasm to the nucleus where it leads to the upregulation of expression of several antioxidant and detoxification genes (e.g., GSTs, SODs, and HO-1), the downregulation of NF-B, and reduction in proinflammatory cytokines (e.g., IL-6 and IL-1)