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In general, such preparatory methods include the step of bringing the active ingredient into association with an excipient and/or one or more other accessory ingredients, and then, if necessary and/or desirable, dividing, shaping and/or packaging the product into a desired single- or multi-dose unit

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The two pathways are complementary, which is why they are frequently studied together

Preferably, these non-naturally occurring nucleic acids and non- naturally occurring nucleotides are located outside the guide sequence

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