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This movement combined with the change in charge introduced by the mutations modifies the binding cavity, forcing glutathione to adopt a nonproductive binding mode and permitting trypanothione and to a certain degree also the weak substrate glutathionylspermidine to assume a productive mode

Though these are a normal part of human metabolism, they cause significant oxidative stress over time, damaging DNA inside cells and leading to premature aging

26080, pp

P38alpha MAPK signaling-a robust therapeutic target for Rab5-mediated neurodegenerative disease

Department of Biochemistry, University of Toronto, Ontario Cancer Institute, Canada

10.3390/ijms242216353 380 WangM.TangG.ZhouC.GuoH.HuZ.HuQ.et al