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Melatonin administration to aged mice also demonstrated the therapeutic utility of this compound in the treatment of age-related cardiac sarcopenia, since it preserved the normal cardiomyocyte structure and restored their number, as well as to reducing -myosin heavy chain expression (a marker of cardiac hypertrophy) in these animals

2017;2(14): e93885

The authors concluded that GH-excess is able to promote severe glomerular damage in mice in the absence of IGF-1, whereas tubular hypertrophy observed in GH-transgenic mice is most likely mediated by concomitant IGF-1 excess

Han S, Liang CP, DeVries-Seimon T, Ranalletta M, Welch CL, Collins-Fletcher K, Accili D, Tabas I, Tall AR

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However, the differences in methodologies and experimental design prevent direct comparison between these studies