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27 These modalities influence ion channel activity, increasing intracellular calcium levels, which are crucial for activating downstream signaling pathways such as calcineurin/NFAT, leading to increased protein synthesis, growth factor production, and accelerated tissue repair

Moreover, although certain peptides exhibit cell-penetrating properties, their translocation efficiency remains generally low, particularly across stringent biological barriers such as the BBB, restricting their therapeutic applicability in hard-to-treat diseases (Table 2)

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Haematologica 107 , 298302