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Because IGF-I exerts anti-inflammatory actions and is important for peripheral glucose uptake, metabolic disturbances in these patients can, in part, be explained by the low IGF-I levels (83)

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However, several recent studies have shown that breast cancer cells express immune inhibitory ligands, such as PD-1, which suppress CD8 T-cell activity and lead to immune resistance in breast cancer 63

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Gender Differences in the Context of Obstructive Sleep Apnea and Metabolic Diseases Allen, J., & Bradley, R.D