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In particular, using 3 different cell lines as digestion simulated models (AGS, Caco-2, and SW1353 cells), the authors demonstrated that a proprietary bromelain extract could decrease IL-8, COX-2, iNOS, and TNF- without affecting cell viability

Scott JG, Warren WC, Beukeboom LW, Bopp D, Clark AG, Giers SD, Hediger M, Jones AK, Kasai S, Leichter CA, Li M, Meisel RP, Minx P, Murphy TD, Nelson, DR, Reid WR, Rinkevich FD, Robertson, HM, Sackton TB, Sattelle DB, Thibaud-Nissen, F, Tomlinson C, van de Zande L, Walden KKO, Wilson RK, Liu N

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[5] This regenerative capacity is particularly important in peripheral neuropathy, where nerve damage may be reversible if caught early and treated appropriately