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Skin color is determined by melanin

Bismuth rarely causes systemic side effects, but can result in black and tarry stools (UMMC 2012

However, negative side effects (skin flushing, stomach upset, diarrhea) usually accompany the supplements, resulting in poor compliance from patients

The same authors have shown that TxnRd2 is also able to control mitochondrial H 2 O 2 levels after a high-fat, high-sucrose diet in the heart but not in skeletal muscle