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It represents the primary cause of pain, functional impairment, and long-term disability among middle-aged and elderly individuals globally ( Photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), has demonstrated unique potential as a non-pharmacological, extracorporeal photobiomodulation (PBM) treatment modality in the management of KOA ( Nevertheless, the clinical application of PBMT in KOA remains controversial, with its heterogeneous efficacy drawing considerable attention

While collagen provides the structural integritythe "scaffold"of our bodies, glutathione acts as the "master protector," shielding those structures from oxidative damage

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Therefore, the ROS pathway in PMN-MDSCs requires closer intercellular contact, while M-MDSCs rely on producing large quantities of NO, ARG1, and other immunosuppressive cytokines for immune suppression

doi: 10.1016/j.abb.2008.02.043

As an exploratory measure, the L-Carnitine Comp score was compared to placebo and no significant difference was observed between these groups ( P = 0.576, Fig