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However, although our genetically engineered mouse model of RMC reproduces the aggressive and metastatic phenotypes observed clinically, there is no perfect equivalence between mouse models and human diseases, and thus, caution must be exercised when extrapolating these findings to the clinic

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doi: 10.1136/gutjnl-2020-323020 105 ZuoTZhanHZhangFLiuQTsoEYKLuiGCYet al

Furthermore, we investigated the metabolic fate of U- 15 N glutamine in vivo by LCMS, which produces glutathione containing one 15 N atom via GSH de novo synthesis (Fig

GSH is synthesized exclusively in the cytosol

Homocysteine and Methylmalonic acid tend to start to rise when the B12 level is below 400pmol/L, so our Naturopathic doctors usually aim for the B12 to be well above 500 pmol/L