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In the mid-to-late 1960s, furosemide was synthetized and quickly gained popularity due to its strong diuretic effects, fast action and effectiveness, especially in treating heart failure, hypertension, edema and kidney failure (Ingram, 1964

Targeting ENL/AF9 offers a promising approach for treating patients with leukemia who have primary or acquired resistance to BETi, potentially in synergy with BET or DOT1L inhibitors [284]

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3 The hepatotoxic effects of APAP overdose are well documented and primarily arise from the metabolic conversion of APAP to reactive metabolites in the liver

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