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10.1038/nrcardio.2017.115 179 RossE

Collectively, these findings demonstrate that TGF modulates the activity of PDH and -KGDH through K430 acetylation-mediated DLD dimerization and enzyme complex assembly

In this process, Axin serves as a scaffold protein, with CKI and GSK-3 sequentially phosphorylating -Catenin, and APC-mediated recognition and eventual degradation of phosphorylated -Catenin by the E3 ubiquitin ligase -TrCP, which maintains the stability of intracellular cytoplasmic levels of -Catenin and prevents the expression of target genes of the pathway (1620)