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Another significant group includes carotenoids such as beta-carotene, lutein, and zeaxanthin, which are found in colorful fruits and vegetables like carrots and spinach [203]

& Kross, R

MathewRKarpCMBeaudoinBVuongNChenGChenHYet al

NAC has been utilised to treat acetaminophen damage because of its antioxidant, anti-inflammatory, and vasodilating properties [63]

Furthermore, oxidative stress impairs nitric oxide (NO) bioavailability, reducing vasodilation and increasing vascular stiffness [188]

For instance, NRF2 inhibitors, such as Brusatol and Brucein D, promote ubiquitination and proteasomal degradation of NRF2, enhancing chemosensitivity in cancers like AML, endometrial cancer, and pancreatic ductal adenocarcinoma