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HIF-1 can upregulate the expression of transferrin receptor (TFR) and HO-1, further increasing intracellular iron levels and inducing ferroptosis in periodontal cells [118]

10.1016/j.psyneuen.2021.105287 Psychoneuroendocrinology 116 GwakY

This is because the deficiency is interlinked with cognitive decline essentially indicating that when your body becomes deficient and lacking in vitamin B12, it can lead to shrinkage of your brain and a decline in brain function

Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response