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2009), while other AAV serotypes have been used for targeting other cell populations in the CNS, such as astrocytes (Hanlon et al

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death

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