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Phase Therapeutic range Weeks 13-16 Weekly Dose 9 mg Notes Skip to 9 mg or hold at 6 mg by tolerance

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Combined treatment with MPE and LGG significantly restored colon morphology, reduced spleen hypertrophy, and suppressed inflammatory cytokines and enhanced GLP-1, Nrf2 expression and SCFA levels, indicating enhanced gut barrier function and microbial homeostasis

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Among these, TNTs, which are F-actin-supported membranous nanotubes with diameters between 50 nm and 1 m, represent a major pathway for astrocyte-mediated transfer of functional mitochondria to compromised neurons [21]

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