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Additionally, polyphenols chelate metal ions like iron and copper, which catalyze the formation of highly reactive hydroxyl radicals through Fenton reactions, further reducing oxidative damage (Fraga et al

The increased expression of immune checkpoint ligand levels in TAMs (such as PD-L1 and PD-L2, etc.) can directly inhibit the activity of T cells

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10.1093/bioinformatics/17.9.847 Bioinformatics 125 ZhangW.YanH.ChenW.LiuJ.JiangC.JiangH.et al (2014)