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The lack of consistent changes in expression of Class I alleles in human or murine PCa cells suggests that the Class I upregulation and consequent CD8-dependent immune response reported in IGF-depleted or inhibited tumors 13,19 may be due not to reduced expression of MHC -chains, but rather to disruption of peptide transport and processing, and downregulation of invariant Class I component 2M

Additionally, PICALM promotes clathrin-mediated endocytosis (CME) by facilitating clathrin-coated vesicle formation

Additionally, research has revealed a complex interplay between lactylation and inflammation [25,26,27,28]

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The disease not only imposes significant physical and emotional burdens on patients but also results in substantial socioeconomic costs

The AUC of p-Ser129--Syn in diluted human serum was 0.92, suggesting its potential value as a biomarker for clinical diagnosis of early PD (Chen et al., 2022)