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1-10 mg/kg in animal studies KPV studies: 100 micromolar oral concentrations in colitis models

Human cancer cell lines used in the present project were purchased from either the American Type Culture Collection (ATCC), The Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures GmbH (DSMZ) or the European Collection of Authenticated Cell Cultures (ECACC)

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Subsequent research has revealed new signaling networks that may play a role in cancer progression or recurrence, and these molecular pathways were emphasized and identified through significant advancements in bioinformatics and next-generation sequencing

Access this article Similar content being viewed by others Abbreviations BMD: Bone mineral density CAT: Catalase COX-2: Cyclooxygenase-2 ECM: Extracellular matrix GPX: Glutathione peroxidase IL-1: Interleukin-1 beta IL-6: Interleukin-6 iNOS: Inducible nitric oxide synthase KBD: Kashin-Beck disease miR-138-5p: MicroRNAs-138-5p MMP13: Matrix metalloproteinase 13 mTOR: Mammalian target of rapamycin OA: Osteoarthritis OP: Osteoporosis OPG: Osteoprotegerin PI3K: Phosphatidylinositol 3-kinase RA: Rheumatoid arthritis ROS: Reactive oxygen species SANFH: Steroid-induced femoral head necrosis Sec: Selenocysteine Se-CPC: Selenium-modified calcium phosphate cement SelM: Selenoprotein M SeMet: Selenomethionine SeNPs: Selenium nanoparticles SOD: Superoxide dismutase TNF-: Tumor necrosis factor alpha TRAP: Tartrate-resistant acid phosphatase TrxR: Thioredoxin reductase References Small-Howard AL, Berry MJ (2005) Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes

This side effect is very common and even the skilled injectors or clinic could not completely prevent it from happening