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These steps do not even require malignancy of the cells as normal mammary cells succeed to achieve seeding if not growth [200]

The expression of SIRTs in primary motoneurons increased after treatment with MCT, the main source of KBs, and SIRT3 had a protective effect on mitochondrial breakage and neuronal death induced by SOD1-G93A [197]

Combination therapies targeting multiple nodes of the -synferroptosisglial axis (e.g., an iron chelator plus an -syn aggregation inhibitor) may yield synergistic effects and overcome compensatory resistance