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Regardless of the use of multiple off label therapies, participants living with PBC globally had evidence of ongoing moderatesevere pruritus, underscoring the unmet need for a symptom-specific therapy targeting pruritus in PBC

Frenken LA, van Lier HJ, Jordans JG, et al

The efficient depletion of gut microbiota after antibiotic treatment was confirmed by detection of bacterial 16S DNA (Supplemental Figure 1C)

Moreover, the affected animals are subjected to slaughter due to poor reproductive performance

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Conclusion We propose several ways to modulate the purinergic system as a potential therapy for CF, like inhibition of P2X7, activation of P2Y2, A2A and A2B receptors and blocking of adenosine deaminase