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This senescence-associated secretory phenotype is a result of the extrusion of cytoplasmic chromatin fragments in senescent cells, which act on the DNA sensing and effector cGAS-STING pathway to drive expression of interferon and NF-kB elements (Dou et al., 2017

References 1 BersukerK.HendricksJ

Urbain P, Bertz H

To investigate ferroptosis in vivo, ferritin and GPX4 protein expression was detected by immunohistochemistry using anti-ferritin and anti-GPX4 antibodies