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(PubMed) Vijayakumar K, Gunny R, Grunewald S, et al

Gene therapy for Glut1 -deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter

The PPAR-PGC-1 axis plays an important role in the regulation of cardiac function

However, no change in oxygen cost or time-trial outcomes has been reported in several trials, which suggests that dose, duration, and training status modulate efficacy