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Compared to healthy controls, MS patients show significantly downregulated expression of TET2 in peripheral blood mononuclear cells (PBMCs), correlating with abnormal methylation patterns in the promoter regions of TET2 and DNMT1 (134)

Increased MMP-2 and MMP-9 expression and activity can affect BBB permeability by proteolysis of extracellular matrix and structural proteins in brain endothelial cells, increasing the BBB breakdown (Figure 2) (Yang et al., 2007

Its chemical name is 2-amino-3-p-hydroxyphenylpropionic acid

Nature 531, 101104

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