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The patients chronic, nonspecific symptomsincluding fatigue, musculoskeletal pain, paresthesia, cognitive disturbances, and optic neuritiswere misattributed to multiple conditions for nearly a decade, with the absence of classic hematologic findings further complicating the diagnosis

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Since CD38 is present on these immunosuppressive cells, Daratumumab significantly induces immunomodulation during response against MM [88]

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