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For instance, the addition of ganitumab, a monoclonal antibody targeting IGF-1R, to carboplatin/paclitaxel chemotherapy in patients with primary epithelial ovarian cancer did not improve progression-free survival in a phase II multicenter controlled trial (65), despite the promising results of IGF-1R inhibition in various preclinical studies (25, 32, 64)

Given the close association between insulin resistance and hepatic fat deposition, polyphenols offer significant therapeutic value in addressing metabolic dysfunction in NAFLD

Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease

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Indian journal of psychiatry