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10.1046/j.1600-0404.2003.00227.x Marini AM, Zaret BS, Beckner RR: Hepatic and renal contributions to valproic acid-induced hyperammonemia

the definition of this profile showed a good level of homogeneity (mean inter-item Spearman 0.25) [41] and has been extensively described previously as belonging to the immuno-metabolic depression (IMD) domain, based on previous findings on individual symptoms with immuno-metabolic dysregulation [2]

Durante un impegno motorio e durante il digiuno, diminuiscono le concentrazioni di ATP e aumentano le concentrazioni di ADP e AMP, che portano all'attivazione della protein chinasi, a sua volta attivata dalla AMP (AMPK)