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However, there is insufficient evidence to support the mechanisms of DSF in preventing renal fibrosis (RF)

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The FDA's guidance on compounded drug products notes that compounding is appropriate when a specific patient's clinical need cannot be met by a commercially available product, but it should not be used to circumvent the drug approval process [2]

Ammonia derived from glutaminolysis is a diffusible regulator of autophagy

Copper supplementation in both animal models and humans (e.g., patients with SCO2 mutations) can restore CCO activity, reverse hypertrophy and fibrosis, and significantly improve cardiac function [51, 52]

In contrast, ubiquitin-independent mitophagy receptors (UIMRs) are pre-localized on organelle membranes and do not directly interact with ubiquitin