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doi:10.1038/s41598-025-04057-6

High levels of acetaldehyde can alter intestinal permeability and microbiota homeostasis, leading to direct liver cell damage (Patel et al., 2022a)

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In our study, prepubertal rats were exposed to acephate, carbendazim, and the dithiocarbamate mancozeb, based on the prevalence of these chemicals in the ANVISA report ( a posteriori test was conducted to investigate the nature of the interaction ( Given that all the agrochemicals studied have been described as reproductive toxicants when administered individually ( Contrary to expectations, our study provides evidence that these agrochemicals, when combined in binary or ternary mixtures, primarily interact in ways that result in antagonistic effects on the reproductive parameters assessed, i.e., the interactions between agrochemicals in mixtures culminated in reduced impact on reproductive parameters, compared to the effects observed when each chemical is tested individually, as detailed below

(Prentice Hall, 2001)