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That depends on the research question

1- Ice the injection site Before injecting with vitamin B12, apply ice to your thigh, hip, or groin- wherever you plan on inserting the needle

For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

Thirty-five were animal studies

So, its recommended to avoid it for at least 24 hours after the treatment

And still no pain