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10.1186/s12877-020-01507-w 71 GuardaG.ZengerM.YazdiA

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(2.1, 4.2, or 8.4 g/kg) for six weeks alleviated hepatic steatosis, oxidative stress, and inflammation in ALD rats via the gutliver axis by modulating the overall structure of the GM, such as maintaining the Firmicutes/Bacteroidetes ratio and reducing the relative abundance of harmful bacteria including Clostridium and Faecalibaculum, while activating the 15d-prostaglandin J2/Peroxisome proliferator-activated receptor (PPAR) and PPAR signaling pathways to lower serum levels of TNF-, IL-1, and IL-6, thereby improving lipid metabolism [121]

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Despite its benefits, challenges persist, including optimizing selenium dosage to prevent toxicity, addressing variability in selenium uptake among species, and minimizing environmental impacts such as soil contamination