proprional l-carnitine VitaMonk GlycoTrax™ GPLC Extra Large Bottle - 120 Capsules of High-Absorption Glycine Propionyl-L-Carnitine with No Artificial Fillers Propionyl-L-carnitine [CAS 20064-19-1] – QuantiMol

doi: 10.1097/MD.0000000000001714 25 CoxL

We'll ask for the half crust and we'll see what they say

Acetaminophen in doses above 2g/day (saturates sulfation and glucuronidation, depletes glutathione catastrophically) R Alcohol (depletes glutathione, NAD+, SAM-e, and directly damages hepatocytes) R Charcoal-grilled meats (heterocyclic amines that undergo bioactivation via sulfation and acetylation, generating DNA-reactive intermediates) R Chronic NSAID use (competes for glucuronidation and amino acid conjugation pathways) Excess fructose (depletes ATP and drives uric acid production, impairing energy-dependent conjugation) R Glyphosate residues on non-organic produce (disrupts glycine metabolism and chelates manganese) R High-dose turmeric or quercetin without cycling (both inhibit SULT1A1 and can paradoxically impair sulfation at high sustained doses) R Processed foods with benzoate preservatives (benzoic acid consumes glycine through conjugation, depleting the glycine pool for other Phase II reactions) R Proton pump inhibitors chronically (reduce magnesium absorption, impair glucuronidation) R Testing These tests can help identify which conjugation pathways are impaired and what is contributing to the dysfunction

Furthermore, increased oxidative DNA damage, renal apoptosis, and organ dysfunction have been reported

Some of the reasons that such diets may be problematic in Hashimotos are that they can: Exacerbate blood sugar issues : Those with Hashimotos often experience blood sugar issues, which can be exacerbated by carbohydrate-heavy vegan and vegetarian diets

doi: 10.1016/j.chembiol.2021.07.022 45 MathiowetzAJOlzmannJA