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Due to the compounds plasma half-life of approximately 3.86.9 hours [4] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

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10.1007/s00109-017-1575-8 23 ChrysohoouC.KolliaN.TousoulisD

These observations suggest that altered DNA methylation may affect biophysical properties of the skin and facilitate the recruitment of neutrophils to the epidermis