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3 Neurochem Int [Gly14]-Humanin protects against beta-amyloid via mitochondria (Jin et al., 2009)HNG preserved mitochondrial membrane potential, blocked cytochrome-c release and reduced apoptosis in amyloid-beta-exposed PC12 cells

In 2023, Qi et al., 2023 reported that the antidiabetic drug mitoglitazone (MGZ) upregulated GPX4 and reduced lipid peroxidation, thereby significantly alleviating renal injury in mice after I/R, providing a new therapeutic strategy to ameliorate renal I/R injury

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This disruption in the intestinal barrier allows food particles and bacterial toxins to slip through the tight junctions (spaces between the cells) lining the digestive tract 1