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Because increased dopamine synthesis has been documented in schizophrenia in the associative striatum independent of antipsychotic exposure [53], it is tempting to expect a positive relationship of Glu and dopamine synthesis in this region

Some of the key features of this work are that they have coupled a potent drug in such as way that this technology can be used to couple practically anything - for example enzymes, toxins, radio-isotope ligands and photodynamic therapy drugs, says Mahendra Deonarain, head of the recombinant antibody therapeutics laboratory at Imperial College London, UK

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The nature of how impaired glutamate cysteine ligase, the enzyme that naturally produces gamma-glutamylcysteine (GGC), can make cells more susceptible to mutagens due to lower glutathione (GSH) [4, 5] has been well studied

Sci Data 7:113

find that the KD plays an important role in the neuroprotection and anti-convulsion via the kynurenine pathway