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Theranostics 12:65276547

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doi: 10.1016/j.ejphar.2020.173090 67 SusserLINguyenM-AGeoffrionMEmertonCOuimetMKhachoMet al

These molecules regulate immune-cell functions by activating G protein-coupled receptors and inhibiting HDAC, thereby preserving systemic homeostasis ( 3 Mechanisms of the gut-lung axis in severe pneumonia-related lung injury 3.1 Pathogenic effects of gut microbiota dysbiosis Respiratory viral infections provoke exaggerated immune responses that release pro-inflammatory mediators, recruit immune cells, and ultimately disrupt gut-microbiota homeostasis, thereby inducing intestinal inflammation ( 3.2 The gut-derived second hit hypothesis In severe pneumonia, primary invasion of lung tissue constitutes the initial insult, whereas the intestine may provide a secondary source of injury